@文章{信息:doi/10.2196/36712，作者=“Giner-Soriano, Maria和de Dios, Vanessa和Ouchi, Dan和Vilaplana-Carnerero, Carles和Monteagudo, M{\ ' o}nica和Morros, Rosa”，标题=“以前接种流感疫苗的人感染COVID-19的结果:使用初级卫生保健电子记录的基于人群的队列研究”，期刊=“JMIR公共卫生监测”，年=“2022”，月=“11”，日=“11”，卷=“8”，数=“11”，页=“e36712”，关键词=“SARS-CoV-2;COVID-19;流感疫苗;肺炎;电子健康记录;初级保健;疫苗接种;公共卫生;队列研究;流行病学; eHeatlh; health outcome; mortality", abstract="Background: A possible link between influenza immunization and susceptibility to the complications of COVID-19 infection has been previously suggested owing to a boost in the immunity against SARS-CoV-2. Objective: This study aimed to investigate whether individuals with COVID-19 could have benefited from vaccination against influenza. We hypothesized that the immunity resulting from the previous influenza vaccination would boost part of the immunity against SARS-CoV-2. Methods: We performed a population-based cohort study including all patients with COVID-19 with registered entries in the primary health care (PHC) electronic records during the first wave of the COVID-19 pandemic (March 1 to June 30, 2020) in Catalonia, Spain. We compared individuals who took an influenza vaccine before being infected with COVID-19, with those who had not taken one. Data were obtained from Information System for Research in Primary Care, capturing PHC information of 5.8 million people from Catalonia. The main outcomes assessed during follow-up were a diagnosis of pneumonia, hospital admission, and mortality. Results: We included 309,039 individuals with COVID-19 and compared them on the basis of their influenza immunization status, with 114,181 (36.9{\%}) having been vaccinated at least once and 194,858 (63.1{\%}) having never been vaccinated. In total, 21,721 (19{\%}) vaccinated individuals and 11,000 (5.7{\%}) unvaccinated individuals had at least one of their outcomes assessed. Those vaccinated against influenza at any time (odds ratio [OR] 1.14, 95{\%} CI 1.10-1.19), recently (OR 1.13, 95{\%} CI 1.10-1.18), or recurrently (OR 1.10, 95{\%} CI 1.05-1.15) before being infected with COVID-19 had a higher risk of presenting at least one of the outcomes than did unvaccinated individuals. When we excluded people living in long-term care facilities, the results were similar. Conclusions: We could not establish a protective role of the immunity conferred by the influenza vaccine on the outcomes of COVID-19 infection, as the risk of COVID-19 complications was higher in vaccinated than in unvaccinated individuals. Our results correspond to the first wave of the COVID-19 pandemic, where more complications and mortalities due to COVID-19 had occurred. Despite that, our study adds more evidence for the analysis of a possible link between the quality of immunity and COVID-19 outcomes, particularly in the PHC setting. ", issn="2369-2960", doi="10.2196/36712", url="https://publichealth.www.mybigtv.com/2022/11/e36712", url="https://doi.org/10.2196/36712", url="http://www.ncbi.nlm.nih.gov/pubmed/36" }