@文章{信息:doi/10.2196/22521，作者="Urbach, Dietmar和Awiszus, Friedemann和Lei{\ss}， Sven和Venton, Tamsin和Specht, Alexander Vincent De和Apfelbacher, Christian"，标题="药物与典型COVID-19症状低几率的相关性:截面症状监测研究"，期刊="JMIR公共卫生监测"，年="2020"，月=" 12月"，日="14"，卷="6"，数="4"，页数="e22521"，关键词="COVID-19;SARS-CoV-2;他汀类药物;降压药;监测;羟甲基戊二酰辅酶A还原酶抑制剂;背景:随着COVID-19大流行继续在全球蔓延，寻找治疗COVID-19症状的有效药物的工作也在继续。最好确定一种已经用于治疗另一种疾病的药物，其副作用和安全性数据已经已知并得到批准。目的:本研究的目的是通过使用在线监测调查的数据，评估不同药物对典型COVID-19症状的影响。方法:在2020年4月初至7月底期间，德国下萨克森州共有3654人通过应用程序covid-nein-danke.de参加了一项在线症状跟踪调查。 The questionnaire comprised items on typical COVID-19 symptoms, age range, gender, employment in patient-facing healthcare, housing status, postal code, previous illnesses, permanent medication, vaccination status, results of reverse transcription polymerase chain reaction (RT-PCR) and antibody tests for COVID-19 diagnosis, and consequent COVID-19 treatment if applicable. Odds ratio estimates with corresponding 95{\%} CIs were computed for each medication and symptom by using logistic regression models. Results: Data analysis suggested a statistically significant inverse relationship between typical COVID-19 symptoms self-reported by the participants and self-reported statin therapy and, to a lesser extent, antihypertensive therapy. When COVID-19 diagnosis was based on restrictive symptom criteria (ie, presence of 4 out of 7 symptoms) or a positive RT-PCR test, a statistically significant association was found solely for statins (odds ratio 0.28, 95{\%} CI 0.1-0.78). Conclusions: Individuals taking statin medication are more likely to have asymptomatic COVID-19, in which case they may be at an increased risk of transmitting the disease unknowingly. We suggest that the results of this study be incorporated into symptoms-based surveillance and decision-making protocols in regard to COVID-19 management. Whether statin therapy has a beneficial effect in combating COVID-19 cannot be deduced based on our findings and should be investigated by further study. Trial Registration: German Clinical Trials Register DRKS00022185; https://www.drks.de/drks{\_}web/navigate.do?navigationId=trial.HTML{\&}TRIAL{\_}ID=DRKS00022185; World Health Organization International Clinical Trials Registry Platform U1111-1252-6946 ", issn="2369-2960", doi="10.2196/22521", url="http://publichealth.www.mybigtv.com/2020/4/e22521/", url="https://doi.org/10.2196/22521", url="http://www.ncbi.nlm.nih.gov/pubmed/33197879" }