杂志文章%@ 2561- 9128% I JMIR出版物%V 5% N卡塔尔世界杯8强波胆分析 1% P使用术中生理反应的高阶奇异值分解预测术后长期疼痛:前瞻性队列研究%A Baharloo,Raheleh %A Principe,Jose %A Rashidi,Parisa %A Tighe,Patrick %+佛罗里达大学，1064 Center Drive, NEB 459，盖恩斯维尔，佛罗里达州，32611,1 352 392 9469,parisa.rashidi@ufl.edu %K张量分解%K多变量时间分解%K长期术后pain %K高阶单值分解%K SVD %D 2022 %7 14.9.2022 %9原论文%J JMIR Perioper Med %G英语%X背景:长期术后疼痛(POP)和患者对镇痛药物的反应尚未完全了解。尽管最近的研究已经开发了一个基于多种生理参数的全麻患者痛觉水平指数，但尚不清楚这些参数是否与长期POP结果相关。目的:本研究旨在通过多变量时间分析，提取无偏的和可解释的描述生理参数的动态变化如何随着时间的推移和患者对手术程序和术中药物的反应。我们证明了术中生理反应的主要特征与长期POP之间存在相关性，即使不声明因果关系，也具有预测价值。方法:提出一种复杂的高阶奇异值分解方法，将患者的生理反应精确地分解为随时间变化的多元结构。我们使用来自混合手术队列的175例患者的术中生命体征，提取患者生理反应的三种相互关联的、低维的、复杂值的描述:反映亚生理参数的多变量因素;时间因素，反映常见的术中时间动态;以及患者因素，描述患者间生理反应的变化。 Results: Adoption of the complex higher-order singular value decomposition method allowed us to clarify the dynamic correlation structure included in the intraoperative physiological responses. Instantaneous phases of the complex-valued physiological responses of 242 patients within the subspace of principal descriptors enabled us to discriminate between mild and not-mild (moderate-severe) levels of pain at postoperative days 30 and 90. Following rotation of physiological responses before projection to align with the common multivariate-temporal dynamic, the method achieved an area under curve for postoperative day 30 and 90 outcomes of 0.81 and 0.89 for thoracic surgery, 0.87 and 0.83 for orthopedic surgery, 0.87 and 0.88 for urological surgery, 0.86 and 1 for colorectal surgery, 1 and 1 for transplant surgery, and 0.83 and 0.92 for pancreatic surgery, respectively. Conclusions: By categorizing patients into different surgical groups, we identified significant surgery-related principal descriptors. Each of them potentially encodes different surgical stimulation. The dynamics of patients’ physiological responses to these surgical events were linked to long-term POP development. %M 36103231 %R 10.2196/37104 %U https://periop.www.mybigtv.com/2022/1/e37104 %U https://doi.org/10.2196/37104 %U http://www.ncbi.nlm.nih.gov/pubmed/36103231