TY - JOUR AU - Marler, Jennifer D AU - Fujii, Craig A AU - Utley, MacKenzie T AU - Balbierz, Daniel J AU - Galanko, Joseph A AU - Utley, David S PY - 2022 DA - 2022/11/24 TI -综合移动戒烟计划与尼古丁替代疗法在成年吸烟者中的效果:试点随机对照试验JO - JMIR Mhealth Uhealth SP - e41658 VL - 10 IS - 11 KW -戒烟KW -数字健康KW -智能手机KW -数字传感器KW -一氧化碳KW -呼吸传感器KW -生物反馈KW -移动应用KW -健康促进KW -应用KW -手机AB -背景:吸烟仍然是可预防疾病和死亡的主要原因，强调了对基于证据的解决方案的持续需求。Pivot是一项基于美国临床实践指南的移动戒烟计划，包括个人一氧化碳呼吸传感器;智能手机应用程序;应用内、基于文本的人工指导;尼古丁替代疗法;还有一个适度的网络社区。有前景的支点队列研究为比较评估奠定了基础。目的:本研究旨在比较Pivot和QuitGuide(美国国家癌症研究所基于美国临床实践指南的戒烟智能手机应用程序)之间的参与度、保留度、戒烟态度、吸烟行为和参与者反馈。方法:在这项远程试点随机对照试验中，在网上招募了美国的吸烟者，并随机分配到Pivot或QuitGuide。 Participants were offered 12 weeks of free nicotine replacement therapy. Data were self-reported via weekly web-based questionnaires for 12 weeks and at 26 weeks. Outcomes included engagement and retention, attitudes toward quitting smoking, smoking behavior, and participant feedback. The primary outcome was self-reported app openings at 12 weeks. Cessation outcomes included self-reported 7- and 30-day point prevalence abstinence (PPA), abstinence from all tobacco products, and continuous abstinence at 12 and 26 weeks. PPA and continuous abstinence were biovalidated via breath carbon monoxide samples. Results: Participants comprised 188 smokers (94 Pivot and 94 QuitGuide): mean age 46.4 (SD 9.2) years, 104 (55.3%) women, 128 (68.1%) White individuals, and mean cigarettes per day 17.6 (SD 9.0). Engagement via mean “total app openings through 12 weeks” (primary outcome) was Pivot, 157.9 (SD 210.6) versus QuitGuide, 86.5 (SD 66.3; P<.001). Self-reported 7-day PPA at 12 and 26 weeks was Pivot, 35% (33/94) versus QuitGuide, 28% (26/94; intention to treat [ITT]: P=.28) and Pivot, 36% (34/94) versus QuitGuide, 27% (25/94; ITT: P=.12), respectively. Self-reported 30-day PPA at 12 and 26 weeks was Pivot, 29% (27/94) versus QuitGuide, 22% (21/94; ITT: P=.32) and Pivot, 32% (30/94) versus QuitGuide, 22% (21/94; ITT: P=.12), respectively. The biovalidated abstinence rate at 12 weeks was Pivot, 29% (27/94) versus QuitGuide, 13% (12/94; ITT: P=.008). Biovalidated continuous abstinence at 26 weeks was Pivot, 21% (20/94) versus QuitGuide, 10% (9/94; ITT: P=.03). Participant feedback, including ease of setup, impact on smoking, and likelihood of program recommendation were favorable for Pivot. Conclusions: In this randomized controlled trial comparing the app-based smoking cessation programs Pivot and QuitGuide, Pivot participants had higher engagement and biovalidated cessation rates and more favorable user feedback at 12 and 26 weeks. These findings support Pivot as an effective, durable mobile smoking cessation program. Trial Registration: ClinicalTrials.gov NCT04955639; https://clinicaltrials.gov/ct2/show/NCT04955639 SN - 2291-5222 UR - https://mhealth.www.mybigtv.com/2022/11/e41658 UR - https://doi.org/10.2196/41658 UR - http://www.ncbi.nlm.nih.gov/pubmed/36257323 DO - 10.2196/41658 ID - info:doi/10.2196/41658 ER -