TY - JOUR AU - Torres, Luisa AU - Lee, Joy L AU - Park, Seho AU - Di Lorenzo, R Christian AU - Branam, Jonathan P AU - Fraser, Shelagh A AU - Salisbury, Benjamin A PY - 2022 DA - 2022/10/4 TI -保留，禁食模式和间歇性禁食应用程序减肥:大规模，52周的观察性研究JO - JMIR Mhealth Uhealth SP - e35896 VL - 10 IS - 10 KW -间歇性禁食KW -限时进食KW -减肥KW -肥胖KW -移动应用KW -饮食追踪器KW -保留AB背景:间歇性禁食(IF)是一种日益流行的饮食控制方法，其重点是进食的时间而不是热量摄入的数量和含量。如果从业者通常寻求改善他们的体重和其他健康因素。数以百万计的从业者已经转向专门开发的移动应用程序来帮助他们跟踪和坚持他们的禁食，并监测他们的体重和其他生物特征的变化。目的:本研究旨在量化两款IF手机应用的用户留存率、禁食模式和减肥情况。我们还试图描述和建模起始BMI、禁食量、体重跟踪频率和其他与保持和体重变化相关的人口统计数据。方法:我们收集了2018年至2020年使用LIFE禁食追踪器和LIFE Extend应用程序的成年用户(18-100岁)的身高、体重、禁食和人口统计数据。52周的留存率是根据记录的速度和用户统计数据进行量化的。提供身高和至少两次体重读数的用户，其第一次快速和体重记录是同时发生的，都被纳入减肥分析。禁食被量化为延长禁食时间(EFH; hours beyond 12 in a fast) averaged per day (EFH per day). Retention was modeled using a Cox proportional hazards regression. Weight loss was analyzed using linear regression. Results: A total of 792,692 users were followed for retention based on 26 million recorded fasts. Of these, 132,775 (16.7%) users were retained at 13 weeks, 54,881 (6.9%) at 26 weeks, and 16,478 (2.1%) at 52 weeks, allowing 4 consecutive weeks of inactivity. The survival analysis using Cox regression indicated that retention was positively associated with age and exercise and negatively associated with stress and smoking. Weight loss in the qualifying cohort (n=161,346) was strongly correlated with starting BMI and EFH per day, which displayed a positive interaction. Users with a BMI ≥40 kg/m2 lost 13.9% of their starting weight by 52 weeks versus a slight weight gain on average for users with starting BMI <23 kg/m2. EFH per day was an approximately linear predictor of weight loss. By week 26, users lost over 1% of their starting weight per EFH per day on average. The regression analysis using all variables was highly predictive of weight change at 26 weeks (R2=0.334) with starting BMI and EFH per day as the most significant predictors. Conclusions: IF with LIFE mobile apps appears to be a sustainable approach to weight reduction in the overweight and obese population. Healthy weight and underweight individuals do not lose much weight on average, even with extensive fasting. Users who are obese lose substantial weight over time, with more weight loss in those who fast more. SN - 2291-5222 UR - https://mhealth.www.mybigtv.com/2022/10/e35896 UR - https://doi.org/10.2196/35896 UR - http://www.ncbi.nlm.nih.gov/pubmed/36194463 DO - 10.2196/35896 ID - info:doi/10.2196/35896 ER -