%0杂志文章%@ 2291-5222 %I JMIR出版物%V 8% 卡塔尔世界杯8强波胆分析N 8% P e17408% T早期乳腺癌全身治疗期间症状管理和相关生活质量的移动应用程序:非随机对照前瞻性队列研究%A graitic Kuhar,Cvetka %A Gortnar Cepeda, tjaka %A kovatic,Timotej %A Kukar,Matjaž %A ruiic Gorenjec,Nina %+卢布尔雅那肿瘤研究所肿瘤内科，zalohka 2，卢布尔雅那，si1000，斯洛文尼亚，386 1 5879 287,cgrasic@onko-i.si %K乳腺癌%K全身治疗%K移动应用%K患者报告结果%K生活质量%D 2020 %7 4.8.2020 %9原始论文%J JMIR Mhealth Uhealth %G英文%X背景:为正在接受全身治疗的癌症患者提供有关症状管理的有用信息，对于防止生活质量不必要的恶化至关重要。目的:目的是评估症状管理应用程序的使用是否与患者生活质量或卫生资源使用的任何变化相关。方法:在斯洛文尼亚卢布尔雅那肿瘤学研究所招募接受全身治疗的早期乳腺癌门诊患者。2017年12月至2018年3月(对照组)和2018年4月至2018年9月(干预组)接受全身治疗的患者符合条件。所有患者都接受了标准治疗，但只有干预组的患者被要求使用基于android的智能手机应用mPRO Mamma。该应用程序支持每天跟踪50种症状，允许用户对症状的严重程度进行分级(轻度、中度或严重)，并根据报告的症状级别提供深入的描述和建议。两组患者报告的结果通过欧洲癌症研究与治疗组织(EORTC)核心(C-30)和乳腺癌(BR-23)问卷以及关于卫生资源使用的问卷进行评估。主要结果为3个时间段(治疗第一周、第一个治疗周期和整个治疗期间)后组间总体生活质量的差异和组间EORTC C-30问卷总结性评分的差异。 The secondary outcome was the use of health resources (doctor visits and hospitalizations) in each time period. Other scales were used for exploratory analysis. Results: The mean difference between the intervention group (n=46) and the control group (n=45) in global quality of life (adjusted for baseline and type of surgery) after the first week was 10.1 (95% CI 1.8 to 18.5, P=.02). The intervention group summary scores were significantly higher than those of the control group after the first week (adjusted mean difference: 8.9, 95% CI 3.1 to 14.7, P=.003) and at the end of treatment (adjusted mean difference: 10.6, 95% CI 3.9 to 17.3, P=.002). Use of health resources was not statistically significant between the groups in either the first week (P=.12) or the first treatment cycle (P=.13). Exploratory analysis findings demonstrated clinically important improvements (indicated by EORTC C-30 or BR-23 scale scores)—social, physical, role, and cognitive function were improved while pain, appetite loss, and systemic therapy side effects were reduced. Conclusions: Use of the app enabled patients undergoing systemic therapy for early stage breast cancer to better cope with symptoms which was demonstrated by a better global quality of life and summary score after the first week and by a better summary score at the end of treatment in the intervention group compared to those of the control group, but no change in the use of health resources was demonstrated. %M 32427567 %R 10.2196/17408 %U https://mhealth.www.mybigtv.com/2020/8/e17408 %U https://doi.org/10.2196/17408 %U http://www.ncbi.nlm.nih.gov/pubmed/32427567