@文章{信息:doi/10.2196/38181，作者=“Denis, Fabrice和Maurier, Laura和Carillo, Kevin和Ologeanu-Taddei, Roxana和Septans, Anne-Lise和Gepner, Agnes和Le Goff, Florian和Desbois, Madhu和Demurger, Baptiste和Silber, Denise和Zeitoun, Jean-David和Assuied, Guedalia Peretz和Bonnot, Olivier”，标题=“通过移动健康应用程序对幼儿神经发育障碍和产后抑郁症的早期检测:“观察性横断面研究”，期刊=“JMIR Mhealth Uhealth”，年=“2022”，月=“5”，日=“16”，卷=“10”，数=“5”，页=“e38181”，关键词=“早期发现”;NDD;神经发育障碍;自闭症谱系障碍;自闭症谱系障碍;患产后抑郁症;产后抑郁症;移动健康;移动健康; real-world study; autism; parenting; pediatric; children; mobile phone; smartphone; mobile health app; digital health intervention; digital product; algorithm", abstract="Background: Delays in the diagnosis of neurodevelopmental disorders (NDDs) in toddlers and postnatal depression (PND) in mothers are major public health issues. In both cases, early intervention is crucial. Objective: We aimed to assess if a mobile app named Malo can reduce delay in the recognition of NDD and PND. Methods: We performed an observational, cross-sectional, data-based study in a population of young parents with a minimum of 1 child under 3 years of age at the time of inclusion and using Malo on a regular basis. We included the first 4000 users matching the criteria and agreeing to participate between November 11, 2021, and January 14, 2022. Parents received monthly questionnaires via the app, assessing skills on sociability, hearing, vision, motricity, language of their infants, and possible autism spectrum disorder. Mothers were also requested to answer regular questionnaires regarding PND, from 4-28 weeks after childbirth. When any patient-reported outcomes matched predefined criteria, an in-app notification was sent to the user, recommending the booking of an appointment with their family physician or pediatrician.The main outcomes were the median age of the infant at the time of notification for possible NDD and the median time of PND notifications after childbirth. One secondary outcome was the relevance of the NDD notification for a consultation as assessed by the physicians. Results: Among 4242 children assessed by 5309 questionnaires, 613 (14.5{\%}) had at least 1 disorder requiring a consultation. The median age of notification for possible autism spectrum, vision, audition, socialization, language, or motor disorders was 11, 9, 17, 12, 22, and 4 months, respectively. The sensitivity of the alert notifications of suspected NDDs as assessed by the physicians was 100{\%}, and the specificity was 73.5{\%}. Among 907 mothers who completed a PND questionnaire, highly probable PND was detected in 151 (16.6{\%}) mothers, and the median time of detection was 8-12 weeks. Conclusions: The algorithm-based alert suggesting NDD was highly sensitive with good specificity as assessed by real-life practitioners. The app was also efficient in the early detection of PND. Our results suggest that the regular use of this multidomain familial smartphone app would permit the early detection of NDD and PND. Trial Registration: ClinicalTrials.gov NCT04958174; https://clinicaltrials.gov/ct2/show/NCT04958174 ", issn="2291-5222", doi="10.2196/38181", url="https://mhealth.www.mybigtv.com/2022/5/e38181", url="https://doi.org/10.2196/38181", url="http://www.ncbi.nlm.nih.gov/pubmed/35576565" }