@文章{信息:doi/10.2196/41658，作者=“Marler, Jennifer D和Fujii, Craig A和Utley, MacKenzie T和Balbierz, Daniel J和Galanko, Joseph A和Utley, David S”，标题=“成人吸烟者综合移动戒烟计划与尼古丁替代疗法的结果:试点随机对照试验”，期刊=“JMIR Mhealth Uhealth”，年=“2022”，月=“11”，日=“24”，卷=“10”，数=“11”，页=“e41658”，关键词=“戒烟;数字健康;智能手机;数字传感器;一氧化碳;呼吸传感器;生物反馈;移动应用;健康促进;应用程序; mobile phone", abstract="Background: Cigarette smoking remains the leading cause of preventable illness and death, underscoring ongoing need for evidence-based solutions. Pivot, a US Clinical Practice Guideline--based mobile smoking cessation program, comprises a personal carbon monoxide breath sensor; a smartphone app; in-app, text-based human-provided coaching; nicotine replacement therapy; and a moderated web-based community. Promising Pivot cohort studies have established the foundation for comparative assessment. Objective: This study aimed to compare engagement, retention, attitudes toward quitting smoking, smoking behavior, and participant feedback between Pivot and QuitGuide, a US Clinical Practice Guideline--based smoking cessation smartphone app from the National Cancer Institute. Methods: In this remote pilot randomized controlled trial, cigarette smokers in the United States were recruited on the web and randomized to Pivot or QuitGuide. Participants were offered 12 weeks of free nicotine replacement therapy. Data were self-reported via weekly web-based questionnaires for 12 weeks and at 26 weeks. Outcomes included engagement and retention, attitudes toward quitting smoking, smoking behavior, and participant feedback. The primary outcome was self-reported app openings at 12 weeks. Cessation outcomes included self-reported 7- and 30-day point prevalence abstinence (PPA), abstinence from all tobacco products, and continuous abstinence at 12 and 26 weeks. PPA and continuous abstinence were biovalidated via breath carbon monoxide samples. Results: Participants comprised 188 smokers (94 Pivot and 94 QuitGuide): mean age 46.4 (SD 9.2) years, 104 (55.3{\%}) women, 128 (68.1{\%}) White individuals, and mean cigarettes per day 17.6 (SD 9.0). Engagement via mean ``total app openings through 12 weeks'' (primary outcome) was Pivot, 157.9 (SD 210.6) versus QuitGuide, 86.5 (SD 66.3; P<.001). Self-reported 7-day PPA at 12 and 26 weeks was Pivot, 35{\%} (33/94) versus QuitGuide, 28{\%} (26/94; intention to treat [ITT]: P=.28) and Pivot, 36{\%} (34/94) versus QuitGuide, 27{\%} (25/94; ITT: P=.12), respectively. Self-reported 30-day PPA at 12 and 26 weeks was Pivot, 29{\%} (27/94) versus QuitGuide, 22{\%} (21/94; ITT: P=.32) and Pivot, 32{\%} (30/94) versus QuitGuide, 22{\%} (21/94; ITT: P=.12), respectively. The biovalidated abstinence rate at 12 weeks was Pivot, 29{\%} (27/94) versus QuitGuide, 13{\%} (12/94; ITT: P=.008). Biovalidated continuous abstinence at 26 weeks was Pivot, 21{\%} (20/94) versus QuitGuide, 10{\%} (9/94; ITT: P=.03). Participant feedback, including ease of setup, impact on smoking, and likelihood of program recommendation were favorable for Pivot. Conclusions: In this randomized controlled trial comparing the app-based smoking cessation programs Pivot and QuitGuide, Pivot participants had higher engagement and biovalidated cessation rates and more favorable user feedback at 12 and 26 weeks. These findings support Pivot as an effective, durable mobile smoking cessation program. Trial Registration: ClinicalTrials.gov NCT04955639; https://clinicaltrials.gov/ct2/show/NCT04955639 ", issn="2291-5222", doi="10.2196/41658", url="https://mhealth.www.mybigtv.com/2022/11/e41658", url="https://doi.org/10.2196/41658", url="http://www.ncbi.nlm.nih.gov/pubmed/36257323" }