TY - JOUR AU - Albalwy, Faisal AU - Brass, Andrew AU - Davies, Angela PY - 2021 DA - 2021年11月3日TI -基于区块链的动态同意架构，支持临床基因组数据共享(同意链):概念验证研究JO - JMIR Med Inform SP - e27816 VL - 9 IS - 11 KW -区块链KW -智能合约KW -动态同意KW -临床基因组学KW -数据共享AB -背景:在临床基因组学中，基因数据库和实验室之间共享罕见遗传病信息对于确定变异的致病意义，从而实现罕见遗传病的诊断至关重要。在实践中，对数据治理和安全性的严重关注减少了这种共享。区块链可以为相关各方之间共享基因组数据提供一种安全的方法，从而帮助克服其中一些问题。目的:本研究旨在通过描述基于区块链的动态同意架构来支持临床基因组数据共享，并提供名为ConsentChain的概念验证实现，以探索该架构的性能，从而促进对区块链技术在支持临床基因组数据共享方面的潜在作用的日益增长的认识。方法:从患者论坛捕获consenentchain需求，以识别安全性和同意性问题。consenentchain是在以太坊平台上开发的，在该平台上，智能合约被用于建模患者的行为，患者可以提供或撤回共享其数据的同意;数据创建者，负责收集和存储患者数据;以及需要查询和访问患者数据的数据请求者。详细分析了作为系统处理的事务数量的函数的consenentchain性能。 Results: We describe ConsentChain, a blockchain-based system that provides a web portal interface to support clinical genomic sharing. ConsentChain allows patients to grant or withdraw data requester access and allows data requesters to query and submit access to data stored in a secure off-chain database. We also developed an ontology model to represent patient consent elements into machine-readable codes to automate the consent and data access processes. Conclusions: Blockchains and smart contracts can provide an efficient and scalable mechanism to support dynamic consent functionality and address some of the barriers that inhibit genomic data sharing. However, they are not a complete answer, and a number of issues still need to be addressed before such systems can be deployed in practice, particularly in relation to verifying user credentials. SN - 2291-9694 UR - https://medinform.www.mybigtv.com/2021/11/e27816 UR - https://doi.org/10.2196/27816 UR - http://www.ncbi.nlm.nih.gov/pubmed/34730538 DO - 10.2196/27816 ID - info:doi/10.2196/27816 ER -