%0期刊文章%@ 2291- 9694% I JMIR出版物%V 8%卡塔尔世界杯8强波胆分析 N 11% P e17964 %T联邦知识图可视化环境:交互式生物医学查询语言和Web应用程序接口的开发%A Cox,Steven Ahalt,Stanley Balhoff,James Bizon,Chris Fecho,Karamarie Kebede,Yaphet Morton,Kenneth Tropsha,Alexander Wang,Patrick Xu，复兴计算研究所，北卡罗来纳大学教堂山分校，100 Europa Drive, Suite 540, Chapel Hill, NC, 27517，美国，1 (919)445 9640，scox@renci.org %K知识图%K临床数据%K生物医学数据%K联邦%K本体%K语义协调%K可视化%K应用程序编程接口%K转化科学%K临床实践%D 2020 %7 23.11.2020 %9原始论文%J JMIR Med Inform %G英文%X人们正在努力使用通用的上层本体对大型生物医学知识图进行语义集成，以将面向图的应用程序编程接口(api)与数据联合起来。然而，联邦带来了一些挑战，包括将查询路由到适当的知识源、答案子集的生成和评估、这些答案子集的语义合并以及结果的可视化和探索。目的:我们的目标是开发一个交互式环境，用于联邦知识图的查询、可视化和深入探索。方法:我们开发了一种生物医学查询语言和web应用程序，称为翻译查询语言(TranQL)，用于查询语义联邦知识图并探索查询结果。TranQL使用Biolink数据模型作为高级生物医学本体和API标准，该API标准已被生物医学数据翻译联盟采用，用于指定将查询表示为由TranQL查询语言中的语句编译的Biolink数据元素图的协议。查询被映射到联邦知识源，答案被合并到知识图中，知识图与查询的特定元素之间有映射。TranQL交互式web应用程序包括一个支持用户探索联邦知识图的用户界面。 Results: We developed 2 real-world use cases to validate TranQL and address biomedical questions of relevance to translational science. The use cases posed questions that traversed 2 federated Translator API endpoints: Integrated Clinical and Environmental Exposures Service (ICEES) and Reasoning Over Biomedical Objects linked in Knowledge Oriented Pathways (ROBOKOP). ICEES provides open access to observational clinical and environmental data, and ROBOKOP provides access to linked biomedical entities, such as “gene,” “chemical substance,” and “disease,” that are derived largely from curated public data sources. We successfully posed queries to TranQL that traversed these endpoints and retrieved answers that we visualized and evaluated. Conclusions: TranQL can be used to ask questions of relevance to translational science, rapidly obtain answers that require assertions from a federation of knowledge sources, and provide valuable insights for translational research and clinical practice. %M 33226347 %R 10.2196/17964 %U http://medinform.www.mybigtv.com/2020/11/e17964/ %U https://doi.org/10.2196/17964 %U http://www.ncbi.nlm.nih.gov/pubmed/33226347