%0期刊文章%@ 2291- 9694% I JMIR出版物%V 10卡塔尔世界杯8强波胆分析% N 11% P e37976 %T使用平滑算法自动估计电子健康记录中最可能的药物组合:开发和验证研究%A Ouchi,Dan %A Giner-Soriano,Maria %A Gómez-Lumbreras,Ainhoa %A Vedia Urgell,Cristina %A Torres,Ferran %A Morros,Rosa %+ Fundació Institut Universitari per A la recerca A l'Atenció Primària de Salut Jordi Gol i Gurina, Gran Via de les Corts Catalanes 587， àtic，巴塞罗那，08007，西班牙，34 934824110，douchi@idiapjgol.info %K电子健康记录%K数据挖掘%K复杂药物模式%K算法%K药物利用%K多药%K EHR %K用药%K药物组合%K治疗%K自动化%K药物展示%K治疗%K坚持%D 2022 %7 15.11.2022 %9原始论文%J JMIR Med Inform %G英文%X背景:自从以自动化的方式使用电子健康记录(EHRs)以来，药物警戒或药物流行病学研究已被用于使用不同的算法来表征治疗。虽然单药治疗在这一领域已经取得了进展，但随着两种或两种以上药物的联合使用，表征治疗的挑战显著增加，需要进行更多的研究。目的:本研究的目标是开发和描述一种新的算法，随着时间的推移，自动返回一种药物或两种或两种以上药物的组合最可能的治疗方法。方法:我们使用初级保健研究信息系统作为我们的参考EHR平台，以便顺利开发算法。该算法受到基于移动平均的统计方法的启发，并依赖于参数Wt，这是一个决定平滑水平的灵活窗口。在相同的数据集，不同的窗口长度的模拟研究中，评估了Wt的效果。为了从临床或药理学的角度了解算法的性能，我们进行了验证研究。 We designed 4 pharmacological scenarios and asked 4 independent professionals to compare a traditional method against the smooth algorithm. Data from the simulation and validation studies were then analyzed. Results: The Wt parameter had an impact over the raw data. As we increased the window length, more patient were modified and the number of smoothed patients augmented, although we rarely observed changes of more than 5% of the total data. In the validation study, significant differences were obtained in the performance of the smooth algorithm over the traditional method. These differences were consistent across pharmacological scenarios. Conclusions: The smooth algorithm is an automated approach that standardizes, simplifies, and improves data processing in drug exposition studies using EHRs. This algorithm can be generalized to almost any pharmacological medication and model the drug exposure to facilitate the detection of treatment switches, discontinuations, and terminations throughout the study period. %M 36378514 %R 10.2196/37976 %U https://medinform.www.mybigtv.com/2022/11/e37976 %U https://doi.org/10.2196/37976 %U http://www.ncbi.nlm.nih.gov/pubmed/36378514