@文章{信息:doi/10.2196/20826，作者=“Oliveira, Carlos R和Niccolai, Patrick和Ortiz, Anette Michelle和Sheth, Sangini S和Shapiro, Eugene D和Niccolai, Linda M和Brandt, Cynthia A”，标题=“自然语言处理用于宫颈癌和宫颈癌前病变的监测:算法开发和分裂验证研究”，期刊=“JMIR Med Inform”，年=“2020”，月=“11”，日=“3”，卷=“8”，数=“11”，页=“e20826”，关键词=“自然语言处理”;自动数据提取;人类乳头状瘤病毒;监测;病理报告;子宫颈癌;肛门癌;癌前期;癌症;人乳头状瘤病毒; accuracy", abstract="Background: Accurate identification of new diagnoses of human papillomavirus--associated cancers and precancers is an important step toward the development of strategies that optimize the use of human papillomavirus vaccines. The diagnosis of human papillomavirus cancers hinges on a histopathologic report, which is typically stored in electronic medical records as free-form, or unstructured, narrative text. Previous efforts to perform surveillance for human papillomavirus cancers have relied on the manual review of pathology reports to extract diagnostic information, a process that is both labor- and resource-intensive. Natural language processing can be used to automate the structuring and extraction of clinical data from unstructured narrative text in medical records and may provide a practical and effective method for identifying patients with vaccine-preventable human papillomavirus disease for surveillance and research. Objective: This study's objective was to develop and assess the accuracy of a natural language processing algorithm for the identification of individuals with cancer or precancer of the cervix and anus. Methods: A pipeline-based natural language processing algorithm was developed, which incorporated machine learning and rule-based methods to extract diagnostic elements from the narrative pathology reports. To test the algorithm's classification accuracy, we used a split-validation study design. Full-length cervical and anal pathology reports were randomly selected from 4 clinical pathology laboratories. Two study team members, blinded to the classifications produced by the natural language processing algorithm, manually and independently reviewed all reports and classified them at the document level according to 2 domains (diagnosis and human papillomavirus testing results). Using the manual review as the gold standard, the algorithm's performance was evaluated using standard measurements of accuracy, recall, precision, and F-measure. Results: The natural language processing algorithm's performance was validated on 949 pathology reports. The algorithm demonstrated accurate identification of abnormal cytology, histology, and positive human papillomavirus tests with accuracies greater than 0.91. Precision was lowest for anal histology reports (0.87, 95{\%} CI 0.59-0.98) and highest for cervical cytology (0.98, 95{\%} CI 0.95-0.99). The natural language processing algorithm missed 2 out of the 15 abnormal anal histology reports, which led to a relatively low recall (0.68, 95{\%} CI 0.43-0.87). Conclusions: This study outlines the development and validation of a freely available and easily implementable natural language processing algorithm that can automate the extraction and classification of clinical data from cervical and anal cytology and histology. ", issn="2291-9694", doi="10.2196/20826", url="https://medinform.www.mybigtv.com/2020/11/e20826", url="https://doi.org/10.2196/20826", url="http://www.ncbi.nlm.nih.gov/pubmed/32469840" }