@Article{info:doi/10.2196/41503，作者=“Bae, Woo Kyung and Cho, Jihoon and Kim, Seok and Kim, Borham and Baek, Hyunyoung and Song, Wongeun and Yoo, Sooyoung”，标题=“冠状动脉ct血管造影预防心脑血管疾病:使用观察性健康数据科学与信息学“公共数据模型”的观察性队列研究，期刊=“JMIR Med Inform”，年=“2022”，月=“Oct”，日=“13”，卷=“10”，号=“10”，页=“e41503”，关键词=“心血管疾病;冠状动脉计算机断层造影;观察性研究;通用数据模型;人口水平估计;心脏病;血管疾病;医学信息学;计算机断层扫描; angiography; electronic health record; risk score; health data science; data modeling", abstract="Background: Cardio-cerebrovascular diseases (CVDs) result in 17.5 million deaths annually worldwide, accounting for 46.2{\%} of noncommunicable causes of death, and are the leading cause of death, followed by cancer, respiratory disease, and diabetes mellitus. Coronary artery computed tomography angiography (CCTA), which detects calcification in the coronary arteries, can be used to detect asymptomatic but serious vascular disease. It allows for noninvasive and quick testing despite involving radiation exposure. Objective: The objective of our study was to investigate the effectiveness of CCTA screening on CVD outcomes by using the Observational Health Data Sciences and Informatics' Observational Medical Outcomes Partnership Common Data Model (OMOP-CDM) data and the population-level estimation method. Methods: Using electronic health record--based OMOP-CDM data, including health questionnaire responses, adults (aged 30-74 years) without a history of CVD were selected, and 5-year CVD outcomes were compared between patients undergoing CCTA (target group) and a comparison group via 1:1 propensity score matching. Participants were stratified into low-risk and high-risk groups based on the American College of Cardiology/American Heart Association atherosclerotic cardiovascular disease (ASCVD) risk score and Framingham risk score (FRS) for subgroup analyses. Results: The 2-year and 5-year risk scores were compared as secondary outcomes between the two groups. In total, 8787 participants were included in both the target group and comparison group. No significant differences (calibration P=.37) were found between the hazard ratios of the groups at 5 years. The subgroup analysis also revealed no significant differences between the ASCVD risk scores and FRSs of the groups at 5 years (ASCVD risk score: P=.97; FRS: P=.85). However, the CCTA group showed a significantly lower increase in risk scores at 2 years (ASCVD risk score: P=.03; FRS: P=.02). Conclusions: Although we could not confirm a significant difference in the preventive effects of CCTA screening for CVDs over a long period of 5 years, it may have a beneficial effect on risk score management over 2 years. ", issn="2291-9694", doi="10.2196/41503", url="https://medinform.www.mybigtv.com/2022/10/e41503", url="https://doi.org/10.2196/41503", url="http://www.ncbi.nlm.nih.gov/pubmed/36227638" }