@文章{信息:doi/10.2196/10347，作者=“Zafar, Sidra和Habboush, Yacob和Beidas, Sary”，标题=“使用分级建议，评估，发展和评估来打击假新闻:怀孕流感疫苗接种的案例研究”，期刊=“JMIR医学教育”，年=“2018”，月=“11月”，日=“07”，卷=“4”，数=“2”，页数=“e10347”，关键词=“GRADE;流感;疫苗接种;自然流产;背景:GRADE (GRADE of Recommendations, Assessment, Development, and Evaluation)框架是一个经过验证的评估工具，用于评估科学出版物的质量。它有助于加强临床医生的决策过程，并支持制定知情的健康政策。目的:本报告有两个目的。首先，我们回顾了观察性研究的解释。第二个目的是分享或提供一个使用GRADE标准的示例。方法:为了说明使用GRADE框架评估出版物，我们选择了一项评估流感疫苗接种后自然流产(SAB)风险的研究。 Results: Since 2004, the Centers for Disease Control and Prevention and the Advisory Committee on Immunization Practice have recommended influenza vaccination of pregnant women. Previous studies have not found an association between influenza vaccination and SAB. However, in a recent case-control study by Donahue et al, a correlation with SAB in women who received the H1N1 influenza vaccine was identified. For women who received H1N1--containing vaccine in the previous and current influenza season, the adjusted odds ratio (aOR) for SAB was 7.7 (95{\%} CI, 2.2-27.3), while the aOR for women not vaccinated in the previous season but vaccinated in the current season was 1.3 (95{\%} CI, 0.7-2.7). Conclusions: Our goal is to enable the readers to critique published literature using appropriate evaluation tools such as GRADE. ", issn="2369-3762", doi="10.2196/10347", url="http://mededu.www.mybigtv.com/2018/2/e10347/", url="https://doi.org/10.2196/10347", url="http://www.ncbi.nlm.nih.gov/pubmed/30404772" }