TY - JOUR AU - Zhu，张开燕AU - Zhang，何琼瑶AU - He，黄炳伟AU - Huang，美珍AU - Lin，荣au - Li, Hong PY - 2022 DA - 2022/2/21 TI -基于沉浸式虚拟现实的认知干预对轻度认知障碍和轻度痴呆老年人认知功能、抑郁和应激感知的改善:试验前后研究JO - JMIR严重游戏SP - e32117 VL - 10 IS - 1kw -认知干预KW -痴呆症KW -沉浸式虚拟现实KW -轻度认知障碍KW -认知障碍KW -虚拟现实KW - VR KW -老年患者KW -可用性KW -记忆KW -压力AB -背景:痴呆症的发病率每年都在增加，对个人、家庭和社会造成不同程度的不良影响。随着计算机信息技术的不断发展，认知干预也在不断发展。使用沉浸式虚拟现实(IVR)作为轻度认知障碍(MCI)和轻度痴呆(MD)的老年人的认知干预是有希望的，尽管只有少数研究关注它的使用。目的:开发中国虚拟超市(CVSM) IVR系统，为老年MCI和MD患者提供全面、个性化的认知干预方案。本研究旨在探讨基于CVSM的5周认知干预的可行性和临床效果。方法:从2020年8月到2021年1月，对31名患有MCI和MD的老年人进行了前测-后测研究设计。所有参与者都使用CVSM系统参加了为期5周的沉浸式虚拟认知训练计划。根据干预后进行的问卷调查，可行性评估为晕屏症状的发生率和严重程度以及参与者的满意度。临床疗效通过神经心理学评估进行评估，包括几种常用的认知功能、抑郁、感知压力和日常生活活动的测量。在基线和干预期后进行测量。 Results: A total of 18 patients with MCI (mean age 82.94 [SD 5.44] years; 12 females) and 13 patients with MD (mean age 85.7 [SD 4.67] years, 10 females) participated in this pilot study. Both groups showed significant improvements in all cognitive function measurements (P<.001). The MD group had a significantly greater improvement in general cognitive function compared to the MCI group in Montreal Cognitive Assessment Scale, Symbol Digit Modalities Test, Shape Trail Test, and Auditory Verbal Learning Test. Furthermore, an intervention effect was observed in the improvement of perceived stress (P=.048 for MD group, P=.03 for MCI group ). Conclusions: The use of the CVSM system may be effective in enhancing the cognitive function of patients with MCI and MD, including general cognitive function, memory, executive function, and attention. IVR technology enriches cognitive intervention approaches and provides acceptable, professional, personalized, and interesting cognitive training for older adults with cognitive impairment. Trial Registration: ClinicalTrials ChiCTR2100043753; https://trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2100043753 SN - 2291-9279 UR - https://games.www.mybigtv.com/2022/1/e32117 UR - https://doi.org/10.2196/32117 UR - http://www.ncbi.nlm.nih.gov/pubmed/35188466 DO - 10.2196/32117 ID - info:doi/10.2196/32117 ER -