期刊文章虚拟现实运动-认知训练在社区居住的认知虚弱老年人中的可行性和效卡塔尔世界杯8强波胆分析果:试验性随机对照试验%关爱安、赵耀卓%刘雅、雅瓦%方雅、奈权%秦雅、梁静%阿、郭国元%单雅娴、靳素雯%韩雅娴、碧媛%孙雅恩、谢丽雅W %A、黎文琪%A、Claudia KY %+香港理工大学护理学院老年护理中心，GH502，中国香港九龙红磡(香港)852 2766 6546，rick.kwan@polyu.edu.hk %K虚拟现实%K运动认知训练%K认知衰弱%K游戏%K可行性%K VR %K训练%K老年人%K虚弱%K初步研究%K随机对照试验%D 2021 %7 6.8.2021 %9原论文%J JMIR严重游戏%G英语%X背景:认知衰弱是指身体虚弱和认知障碍并存的一种疾病，与许多不良的健康结果相关。虽然认知能力弱在老年人中普遍存在，但运动认知训练在增强认知和身体功能方面是有效的。我们提出了一个虚拟现实(VR)同步运动认知训练项目，它允许老年人在模拟真实环境的虚拟空间中进行日常活动。目的:我们旨在(1)探索对认知虚弱老年人提供VR同步运动认知训练的可行性，(2)比较其与社区现有的运动认知训练项目对认知虚弱老年人认知功能和身体功能的影响。方法:采用双臂(1:1)、评盲、平行设计、随机对照试验。参与者的资格标准为:(1)年龄≥60岁，(2)居住在社区，(3)有认知障碍。干预组在虚拟现实平台上同时接受认知训练(即认知游戏)和运动训练(即在运动计上骑车)，模拟老年人的日常生活活动。对照组在平板电脑上接受认知训练(即认知游戏)，在非虚拟现实平台上接受运动训练(即在运动计上骑车)。 Both groups received a 30-minute session twice a week for 8 weeks. Feasibility was measured by adherence, adverse outcomes, and successful learning. The outcomes were cognitive function, physical frailty level, and walking speed. Results: Seventeen participants were recruited and randomized to either the control group (n=8) or intervention group (n=9). At baseline, the median age was 74.0 years (IQR 9.5) and the median Montreal Cognitive Assessment score was 20.0 (IQR 4.0). No significant between-group differences were found in baseline characteristics except in the number of chronic illnesses (P=.04). At postintervention, the intervention group (Z=–2.67, P=.01) showed a significantly larger improvement in cognitive function than the control group (Z=–1.19, P=.24). The reduction in physical frailty in the intervention group (Z=–1.73, P=.08) was similar to that in the control group (Z=–1.89, P=.06). Improvement in walking speed based on the Timed Up-and-Go test was moderate in the intervention group (Z=–0.16, P=.11) and greater in the control group (Z=–2.52, P=.01). The recruitment rate was acceptable (17/33, 52%). Both groups had a 100% attendance rate. The intervention group had a higher completion rate than the control group. Training was terminated for one participant (1/9, 11%) due to minimal VR sickness (Virtual Reality Sickness Questionnaire score=18.3/100). Two participants (2/8, 25%) in the control group withdrew due to moderate leg pain. No injuries were observed in either group. Conclusions: This study provides preliminary evidence that the VR simultaneous motor-cognitive training is effective at enhancing the cognitive function of older people with cognitive frailty. The effect size on frailty was close to reaching a level of significance and was similar to that observed in the control group. VR training is feasible and safe for older people with cognitive frailty. Trial Registration: ClinicalTrials.gov NCT04467216; https://clinicaltrials.gov/ct2/show/NCT04467216 %M 34383662 %R 10.2196/28400 %U https://games.www.mybigtv.com/2021/3/e28400 %U https://doi.org/10.2196/28400 %U http://www.ncbi.nlm.nih.gov/pubmed/34383662