严肃游戏在改善老年人认知障碍患者记忆中的作用卡塔尔世界杯8强波胆分析卡塔尔基金会哈马德·本·哈利法大学科学与工程学院信息与计算技术学院，Abd-alrazaq,Alaa %A Alhuwail,Dari %A Al- jafar,Eiman %A Ahmed,Arfan %A Shuweihdi,Farag %A Reagu,Shuja Mohd %A Househ,Mowafa %+卡塔尔基金会，卡塔尔多哈Al- Luqta St 34110信箱，974 55708549mhouseh@hbku.edu.qa %K严肃游戏%K认知训练%K游戏%K轻度认知障碍%K阿尔茨海默病%K痴呆%K记忆%K系统评价%K荟萃分析%K手机%D回顾%J JMIR严肃游戏%G英语%X背景:众所周知，记忆是主要的认知功能之一，随着年龄的增长而下降。严肃游戏被用来提高老年人的记忆力。许多研究已经评估了严肃游戏在提高记忆力方面的有效性。为了得出关于严肃游戏有效性的明确结论，这些研究的发现需要被汇集和汇总。目的:本研究旨在评估严肃游戏在改善老年认知障碍患者记忆方面的有效性。方法:对随机对照试验进行系统评价。检索来源包括8个数据库、纳入研究的参考文献列表和相关综述，以及引用纳入研究的研究。共有2名审稿人(AA和MH)独立进行了研究选择、数据提取、偏倚风险评估和证据质量评估。 Extracted data were synthesized using a narrative approach and a statistical approach (ie, multilevel meta-analysis), as appropriate. Results: Of the 618 citations retrieved, 18 (2.9%) met the eligibility criteria for this review. Of these 18 studies, 15 (83%) randomized controlled trials were included in 10 multilevel meta-analyses. We found that serious games were more effective than no or passive interventions in improving nonverbal memory (P=.02; standardized mean difference [SMD]=0.46, 95% CI 0.09-0.83) and working memory (P=.04; SMD=0.31, 95% CI 0.01-0.60) but not verbal memory (P=.13; SMD=0.39, 95% CI −0.11 to 0.89). The review also showed that serious games were more effective than conventional exercises in improving verbal memory (P=.003; SMD=0.46, 95% CI 0.16-0.77) but not nonverbal memory (P=.30; SMD=−0.19, 95% CI −0.54 to 0.17) or working memory (P=.99; SMD=0.00, 95% CI −0.45 to 0.45). Serious games were as effective as conventional cognitive activities in improving verbal memory (P=.14; SMD=0.66, 95% CI −0.21 to 1.54), nonverbal memory (P=.94; SMD=−0.01, 95% CI −0.32 to 0.30), and working memory (P=.08; SMD=0.37, 95% CI −0.05 to 0.78) among older adults with cognitive impairment. Finally, the effect of adaptive serious games on working memory was comparable with that of nonadaptive serious games (P=.08; SMD=0.18, 95% CI −0.02 to 0.37). Conclusions: Serious games have the potential to improve verbal, nonverbal, and working memory in older adults with cognitive impairment. However, our findings should be interpreted cautiously given that most meta-analyses were based on a few studies (≤3) and judged to have a low quality of evidence. Therefore, serious games should be offered as a supplement to existing proven and safe interventions rather than as a complete substitute until further, more robust evidence is available. Future studies should investigate the short- and long-term effects of serious games on memory and other cognitive abilities among people of different age groups with or without cognitive impairment. %M 35943792 %R 10.2196/35202 %U https://games.www.mybigtv.com/2022/3/e35202 %U https://doi.org/10.2196/35202 %U http://www.ncbi.nlm.nih.gov/pubmed/35943792