TY -非盟的分支,OraLee H盟——Rikhy Mohit AU - Auster-Gussman,丽莎盟——洛克伍德,金伯利G AU -格雷厄姆,莎拉PY - 2022 DA - 2022/10/27 TI -血压之间的关系减少,体重减轻,在数字App-Based高血压和参与护理计划:观察研究乔- Res JMIR形式SP - e38215六世- 6 - 10 KW -高血压KW -肥胖KW -减肥KW -人工智能会话KW -生活方式教练AB -背景:高血压患者建议进行家庭血压监测;然而，荟萃分析表明，血压的改善与额外的教练支持和自我监测相结合有关，而单独自我监测效果甚微或没有效果。高接触的教练需要大量的资源，并且可能很难通过人工教练模型实现。目的:这项观察性研究评估了在人工智能(AI)指导下参加名为Lark高血压护理的全数字项目后血压和体重的变化。方法:受试者(N=864)的基线收缩压(SBP)≥120 mm Hg，提供了他们的基线体重，并且至少达到了参加项目的第三个月。主要结果是3个月和6个月时收缩压的变化，次要结果是体重的变化以及收缩压和体重变化与参与者人口统计学、特征和项目参与的关系。结果:到第3个月，显著下降-5.4 mm Hg (95% CI -6.5至-4.3;P<.001)。在3到6个月期间，在两个时间点都提供读数的参与者血压没有显著变化(即收缩压下降保持不变)(P=.49)。 Half of the participants achieved a clinically meaningful drop of ≥5 mm Hg by month 3 (178/349, 51.0%) and month 6 (98/199, 49.2%). The magnitude of the drop depended on starting SBP. Participants classified as hypertension stage 2 had the largest mean drop in SBP of –12.4 mm Hg (SE 1.2 mm Hg) by month 3 and –13.0 mm Hg (SE 1.6 mm Hg) by month 6; participants classified as hypertension stage 1 lowered by –5.2 mm Hg (SE 0.8) mm Hg by month 3 and –7.3 mm Hg (SE 1.3 mm Hg) by month 6; participants classified as elevated lowered by –1.1 mm Hg (SE 0.7 mm Hg) by month 3 but did not drop by month 6. Starting SBP (β=.11; P<.001), percent weight change (β=–.36; P=.02), and initial BMI (β=–.56; P<.001) were significantly associated with the likelihood of lowering SBP ≥5 mm Hg by month 3. Percent weight change acted as a mediator of the relationship between program engagement and drop in SBP. The bootstrapped unstandardized indirect effect was –0.0024 (95% CI –0.0052 to 0; P=.002). Conclusions: A hypertension care program with coaching powered by AI was associated with a clinically meaningful reduction in SBP following 3 and 6 months of program participation. Percent weight change was significantly associated with the likelihood of achieving a ≥5 mm Hg drop in SBP. An AI-powered solution may offer a scalable approach to helping individuals with hypertension achieve clinically meaningful reductions in their BP and associated risk of cardiovascular disease and other serious adverse outcomes via healthy lifestyle changes such as weight loss. SN - 2561-326X UR - https://formative.www.mybigtv.com/2022/10/e38215 UR - https://doi.org/10.2196/38215 UR - http://www.ncbi.nlm.nih.gov/pubmed/36301618 DO - 10.2196/38215 ID - info:doi/10.2196/38215 ER -