新冠肺炎疫苗对突破性感染的不良事件发生率及影响:卡塔尔世界杯8强波胆分析A Gabashvili,Irene S %+ Aurametrix, MEBO Research, 13220 SW 35 Terrace, Miami, FL, 33175, United States, 1 4083419355;irene@aurametrix.com %K COVID-19 %K COVID-19疫苗%K疫苗不良事件%K突破性感染%K分散参与性研究%K老年人%K老年人%K医疗服务不足人群%K老龄化%K老年人群%K疫苗接种%K遗传差异%K微生物组差异%K免疫受损%D 2022 %7 4.11.2022 %9原始文件%J JMIR Form Res %G English %X尽管继续努力改善临床研究中服务不足群体的纳入，但多样性方面的差距仍然存在。在面对COVID-19大流行等前所未有的复杂问题时，特殊人群的参与尤为重要。更好地了解不同人群中与免疫反应相关的因素将促进未来的预防和治疗方法。目的:本研究的目的是调查导致COVID-19免疫接种后不良事件的潜在因素。研究人群包括来自农村地区、转型国家和那些医学上未得到充分研究的成年人，年龄范围很广。方法:研究从COVID-19大流行期间建立的同伴支持网络演变而来。参与者是通过在线社区和健康社区以数字方式招募的。 Some of the participants volunteered as study investigators assisting with offline recruitment and safety monitoring. Individuals who consented to participate were asked to share their vaccination experiences either using constantly evolving web-based surveys or via one-on-one communication. Inferential statistical analysis to estimate differences between study groups was performed using parametric and nonparametric tests. Results: Of 1430 participants who shared their vaccination experiences, 648 had outcome measures at their 1.5-year follow-up. Significant differences were found between age groups, types of vaccine adverse events (VAEs), incidences of breakthrough infections, and health conditions linked to the microbiome. Pairwise comparisons showed that VAEs interfering with daily activities were significantly higher in both younger (18-59 years) and older age groups (80-100 years, P<.001) than in the 60-79–year age group. Short-term VAEs were associated with lower incidence of breakthrough COVID-19 infections relative to those who reported either minimal or long-term adverse events (P<.001). A genetic origin was suggested for some adverse reactions. Conclusions: The findings of this study demonstrate that vaccine adverse reactions in older individuals are being overlooked, and the incidence of VAEs impairing immunity may be higher than previously perceived. Better preventive measures are needed for all those at risk for life-threatening and long-term adverse events due to vaccination. Supportive community-based studies focusing on these populations could add important data to the current body of knowledge. Further and more comprehensive studies should follow. Trial Registration: ClinicalTrials.gov NCT04832932; https://clinicaltrials.gov/ct2/show/NCT04832932 International Registered Report Identifier (IRRID): RR2-10.1101/2021.06.28.21256779 %M 36309347 %R 10.2196/41914 %U https://formative.www.mybigtv.com/2022/11/e41914 %U https://doi.org/10.2196/41914 %U http://www.ncbi.nlm.nih.gov/pubmed/36309347