%0杂志文章%@ 2561-326X %I JMIR出版物%V 5% 卡塔尔世界杯8强波胆分析N 7% P e20658%南非儿童产前酒精暴露后的执行功能:横断面研究%A Louw,Jacobus Gidion %A van Heerden,Alastair %A Olivier,Leana %A Lambrechts,Tersius %A brodryk,Mandi %A Bunge,Liska %A Vosloo,Martlé %A Tomlinson,Mark %+酒精相关研究基金会，42 Bloemhof街，开普敦，7535，南非，27216862646，jl@farrsa.org.za %K胎儿酒精谱系障碍%K FASD %K认知%K执行功能%K实验游戏%K脑药物效应%K儿童发育%K严重游戏%K游戏%K酒精%K训练%D 2021 %7 2.7.2021 %9原始论文%J JMIR表格Res %G英语%X背景:酒精是致畸原;在怀孕期间摄入酒精会导致负面的分娩结果，统称为胎儿酒精谱系障碍。影响执行功能发展的高阶认知功能神经发育迟缓是一个常见特征。关于儿童执行功能的研究主要集中在诊断为胎儿酒精谱系障碍的儿童，缺乏关于对未诊断为胎儿酒精谱系障碍但接触过酒精的儿童的影响的信息。目的:本研究的目的是比较4 - 6岁儿童在产前饮酒和未饮酒时执行功能的发展。方法:研究人员招募了接触酒精和未接触酒精的儿童，作为可行性随机对照研究的一部分，评估了基于计算机的认知训练计划，以改善执行功能的发展。这项研究是在南非一个社会经济地位较低的社区进行的，该社区胎儿酒精谱系障碍的患病率很高。评估参与儿童的神经发育; NEPSY-II standardized scores for executive function domains were compared using a multivariate analysis of variance with group membership as the predictor variable. Results: No significant differences in executive functions assessments (P=.39) were found between children in the alcohol-exposed group (n=76) and those in the nonexposed group (n=40). Both groups showed moderate to severe delays in domains. In all but one subtest, the average score for both groups was below the 25th percentile of expected norms. Conclusions: We expected that alcohol exposure would have a measurable impact on executive function development. The lack of differences highlights the prevalence of developmental delays in low–socioeconomic status communities in South Africa and suggests that children are exposed to various threats to cognitive development. International Registered Report Identifier (IRRID): RR2-10.2196/14489 %M 34255647 %R 10.2196/20658 %U https://formative.www.mybigtv.com/2021/7/e20658 %U https://doi.org/10.2196/20658 %U http://www.ncbi.nlm.nih.gov/pubmed/34255647

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