* * * * * * * * * * * * * * * * * *卡塔尔世界杯8强波胆分析 * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * *纵向队列研究A Niemczak,Christopher Fellows,Abigail A Lichtenstein,Jonathan A White-Schwoch,Travis %A Magohe,Albert %A Gui,Jiang %A Wilbur,Jed %A Clavier,Odile %A Massawe,Enica %A Moshi,Ndeserua %A Boivin,Michael %A Kraus,Nina %A Buckey,Jay %+ Geisel达特茅斯医学院，达特茅斯学院，One Medical Center Drive, Lebanon, NH, 03755, usa, 1 603 650 6012，christopher.e.niemczak@dartmouth.edu %K HIV %K中枢听觉功能%K听觉感知%K认知功能%K检测%K认知%K认知功能%K神经认知缺损%K纵向%K听觉%K神经系统%K筛查%K监测%K监测%D 2021 %7 9.2.2021 %9原始论文%J JMIR表格Res %G英文%X背景:HIV感染者神经认知缺损的发展是一个重大的公共卫生问题。以前的横断面研究表明，艾滋病毒感染者在中央听觉测试(CATs)中的表现与认知测试结果相关，但没有纵向数据可以证实。我们一直在对坦桑尼亚达累斯萨拉姆的一组hiv阳性和hiv阴性个体进行中央听觉和认知功能的纵向评估，以了解如何使用中央听觉系统来研究和跟踪中枢神经系统功能障碍的进展。目的:该项目的目标是确定CATs是否可以跟踪艾滋病毒感染者的认知功能随时间的变化轨迹。方法:对382例患者进行了为期3.5年的外周听觉、中枢听觉功能和认知功能测试。每6个月安排一次访问。CATs测试包括听觉时间处理(间隙检测)和噪声中的语音感知(噪声听力测试和三位数测试)。认知测试包括蒙特利尔认知评估(MoCA)、注意力变量测试(TOVA)和Cogstate电池的子测试。 HIV-positive subjects were divided into groups based on their CAT results at their final visit (bottom 20%, top 20%, middle 60%). Primary analyses focused on the comparison between HIV-positive individuals that performed worse on CATs (bottom 20%) and the overall HIV-positive group (middle 60%). Data were analyzed using linear mixed-effect models with time as the main fixed effect. Results: The group with the worst (bottom 20%) CAT performance showed a difference in trajectory for the MoCA (P=.003), TOVA (P<.048), and Cogstate (P<.046) over the course of the study period compared to the overall HIV-positive group. A battery of three CATs showed a significant difference in cognitive trajectory over a relatively short study period of 3.5 years independent of age (bottom 20% vs HIV-positive group). Conclusions: The results of this study support the ability for CATs to track cognitive function over time, suggesting that central auditory processing can provide a window into central nervous system performance. CATs can be simple to perform, and are relatively insensitive to education and socioeconomic status because they only require repeating sentences, numbers, or detecting gaps in noise. These tests could potentially provide a time-efficient, low-cost method to screen for and monitor cognitive decline in patients with HIV, making them a useful surveillance tool for this major public health problem. %M 33470933 %R 10.2196/26406 %U http://formative.www.mybigtv.com/2021/2/e26406/ %U https://doi.org/10.2196/26406 %U http://www.ncbi.nlm.nih.gov/pubmed/33470933