TY -的盟Hettiarachchi Chirath盟——Daskalaki Elena盟——Desborough,简非盟-诺兰,Christopher J AU -奥尼尔,大卫AU - Suominen,汉娜PY - 2022 DA - 2022/2/24 TI -将多个输入集成到一个人造胰腺系统:叙述文献综述乔- JMIR糖尿病SP - e28861六世- 7 - 1 KW -糖尿病,类型1 KW -胰腺,人工KW -算法KW -多变量分析KW -胰岛素输注系统KW -控制系统AB -背景:1型糖尿病(T1D)是一种慢性自身免疫性疾病，胰岛素分泌不足损害机体葡萄糖稳态。皮下持续输注胰岛素是一种常用的治疗方法。人工胰腺系统(APS)使用连续的葡萄糖水平监测和连续的皮下注射胰岛素在一个闭环模式，结合控制器(或控制算法)。然而，由于饮食、运动、压力、睡眠、疾病、葡萄糖感知和胰岛素作用延迟以及认知负担等复杂因素，APS的操作具有挑战性。为了克服这些挑战，研究人员正在研究通过集成额外输入来增强APS，创建多输入APS (MAPS)。目的:本调查的目的是识别和分析MAPS的输入数据、控制架构和验证方法，以更好地了解此类系统的复杂性和当前状态。预计这对开发改进的系统以提高T1D患者的生活质量很有价值。方法:使用Scopus、PubMed和IEEE Xplore数据库进行2005年1月1日至2020年2月10日的文献调查。根据搜索标准，初步筛选出1092篇文章，其中11篇(1.01%)进行深度叙事分析。 In addition, 6 clinical studies associated with the selected studies were also analyzed. Results: Signals such as heart rate, accelerometer readings, energy expenditure, and galvanic skin response captured by wearable devices were the most frequently used additional inputs. The use of invasive (blood or other body fluid analytes) inputs such as lactate and adrenaline were also simulated. These inputs were incorporated to switch the mode of the controller through activity detection, directly incorporated for decision-making and for the development of intermediate modules for the controller. The validation of the MAPS was carried out through the use of simulators based on different physiological models and clinical trials. Conclusions: The integration of additional physiological signals with continuous glucose level monitoring has the potential to optimize glucose control in people with T1D through addressing the identified limitations of APS. Most of the identified additional inputs are related to wearable devices. The rapid growth in wearable technologies can be seen as a key motivator regarding MAPS. However, it is important to further evaluate the practical complexities and psychosocial aspects associated with such systems in real life. SN - 2371-4379 UR - https://diabetes.www.mybigtv.com/2022/1/e28861 UR - https://doi.org/10.2196/28861 UR - http://www.ncbi.nlm.nih.gov/pubmed/35200143 DO - 10.2196/28861 ID - info:doi/10.2196/28861 ER -