TY - JOUR AU - Lu, Justin Di AU - Gotesman, Ryan D AU - Varghese, Shawn AU - Fleming, Patrick AU - Lynde, Charles W PY - 2022 DA - 2022/3/30 TI -原发性妄想症侵袭治疗:系统评价JO - JMIR Dermatol SP - e34323 VL - 5is - 1kw -妄想症感染KW - Morgellons病KW -治疗KW -妄想症寄生虫病KW -非典型KW -典型KW -抗精神病药KW - SSRI KW -妄想症KW -罕见疾病KW -系统评价KW -药理学KW -药理学KW -精神病学KW -皮肤学KW -皮肤科医生KW -药物AB -背景:妄想症侵袭，也被称为Ekbom综合征，是一种罕见的妄想症，其特征是固定的信念，认为自己被寄生虫，蠕虫，昆虫或其他生物感染。虽然妄想症是一种精神疾病，但患者经常向皮肤科医生咨询皮肤检查结果，目前尚不清楚对这种疾病推荐什么治疗方法。目的:我们旨在系统地回顾和描述原发性妄想症侵袭患者的治疗和管理。方法:使用Ovid对MEDLINE、Embase、PsycINFO和Cochrane临床试验登记册进行系统检索。提取并分析相关数据，包括治疗、剂量、缓解、依从性和副作用。结果:共纳入15个病例系列，280例患者(平均年龄53.3岁，女性65.4%)患有妄想症。总体而言，阿立哌唑的完全缓解率最高，为79%(11/14)，尽管这仅限于14例患者。在药物类别中，选择性血清素再摄取抑制剂是最有效的，对合并抑郁、焦虑或拔毛症的患者有79%(11/14)的完全缓解率和43%(9/21)的部分缓解率。 First-generation antipsychotics and second-generation antipsychotics had similar complete remission rates (56/103, 54.4% vs 56/117, 47.9%, respectively) and partial remission rates (36/103, 35% vs 41/117, 35%, respectively). Conclusions: Due to the rarity of delusional infestation, we only found 15 case series. However, we found that first-generation antipsychotics appear to be similar in effectiveness to second-generation antipsychotics for the treatment of primary delusional infestation. Larger studies and randomized controlled trials are needed to evaluate the efficacy of pharmacological therapy for delusional infestation. Trial Registration: PROSPERO CRD42020198161; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=198161 SN - 2562-0959 UR - https://derma.www.mybigtv.com/2022/1/e34323 UR - https://doi.org/10.2196/34323 DO - 10.2196/34323 ID - info:doi/10.2196/34323 ER -