@文章{信息:doi/10.2196/37526，作者=“Neil, Jordan M和Senecal, Christian和Ballini, Lauren和Chang, Yuchiao和Goshe, Brett和Flores, Efren和Ostroff, Jamie S和Park, Elyse R”，标题=“烟草治疗试验招募信息的多方法评估:新近诊断为癌症的当前吸烟者:试验阶因随机控制试验”，期刊=“JMIR癌症”，年=“2022”，月=“8”，日=“24”，卷=“8”，数=“3”，页=“e37526”，关键词=“可教的时刻;癌症;烟草处理试验;吸烟;消息分帧;背景:癌症诊断可以促进戒烟的动机。烟草治疗试验提供了戒烟资源，但应计率较低。数字推广可能会提高收益，但如何最好地招募最近被诊断为吸烟者的知识有限。目的:本研究旨在确定最有效的信息框架，以促进与医生交谈的意愿，参与最近诊断为癌症的吸烟者的烟草治疗试验。方法:从2019年2月至4月，从一个国家网络小组招募了过去24个月内诊断出的当前吸烟者，进行了一项多方法试点随机试验(N=99)。 Participants were randomized to a 2{\texttimes}3 plus control factorial design that tested 3 unique message frames: proximal versus distal threats of smoking, costs of continued smoking versus benefits of quitting, and gains of participating versus losses of not participating in a tobacco treatment trial. The primary outcome was intent to talk to a physician about participating in a tobacco treatment trial. In phase 1, the main effect within each message factor level was examined using ANOVA and compared with the control condition. Other message evaluation and effectiveness measures were collected and explored in a multivariable model predicting intent to talk to a physician. In phase 2, open-text evaluations of the messages were analyzed using natural language processing software (Leximancer) to generate a thematic concept map and Linguistic Inquiry Word Count to identify and compare the prevalence of linguistic markers among message factors. Results: Of the 99 participants, 76 (77{\%}) completed the intervention. Participants who received the cost of continued smoking frame were significantly more likely to intend to talk to their physician about participating in a tobacco treatment trial than those who received the benefits of the quitting frame (mean costs 5.13, SD 1.70 vs mean benefits 4.23, SD 1.86; P=.04). Participants who received the proximal risks of continued smoking frame were significantly more likely to seek more information about participating (mean distal 4.83, SD 1.61 vs mean proximal 5.55, SD 1.15; P=.04), and those who received the losses of not participating frame reported significantly improved perceptions of smoking cessation research (mean gain 3.98, SD 0.83 vs mean loss 4.38, SD 0.78; P=.01). Male participants (P=.006) and those with greater message relevancy (P=.001) were significantly more likely to intend to talk to their physician. Participants' perceptions of their smoking habits, as well as their motivation to quit smoking, were prevalent themes in the open-text data. Differences in the percentages of affective words across message frames were identified. Conclusions: Multimethod approaches are needed to develop evidence-based recruitment messages for patients recently diagnosed with cancer. Future tobacco treatment trials should evaluate the effectiveness of different message frames on smoker enrollment rates. Trial Registration: Clinicaltrials.gov NCT05471284; https://clinicaltrials.gov/ct2/show/NCT05471284 ", issn="2369-1999", doi="10.2196/37526", url="https://cancer.www.mybigtv.com/2022/3/e37526", url="https://doi.org/10.2196/37526", url="http://www.ncbi.nlm.nih.gov/pubmed/36001378" }