@文章{信息:doi/10.2196/30715，作者=“罗，陈，吉，开元，唐，玉龙，杜志远”，标题=“探究专业人士和非专业人士对COVID-19疫苗的表达差异:文本挖掘方法”，期刊=“J医学互联网研究”，年=“2021”，月=“8”，日=“27”，卷=“23”，数=“8”，页数=“e30715”，关键词=“COVID-19;疫苗;乎;结构主题建模;医学专业;非专业人员;不良反应;疫苗接种;疫苗的有效性;背景:COVID-19仍在全球范围内猖獗。 Until now, the COVID-19 vaccine is the most promising measure to subdue contagion and achieve herd immunity. However, public vaccination intention is suboptimal. A clear division lies between medical professionals and laypeople. While most professionals eagerly promote the vaccination campaign, some laypeople exude suspicion, hesitancy, and even opposition toward COVID-19 vaccines. Objective: This study aims to employ a text mining approach to examine expression differences and thematic disparities between the professionals and laypeople within the COVID-19 vaccine context. Methods: We collected 3196 answers under 65 filtered questions concerning the COVID-19 vaccine from the China-based question and answer forum Zhihu. The questions were classified into 5 categories depending on their contents and description: adverse reactions, vaccination, vaccine effectiveness, social implications of vaccine, and vaccine development. Respondents were also manually coded into two groups: professional and laypeople. Automated text analysis was performed to calculate fundamental expression characteristics of the 2 groups, including answer length, attitude distribution, and high-frequency words. Furthermore, structural topic modeling (STM), as a cutting-edge branch in the topic modeling family, was used to extract topics under each question category, and thematic disparities were evaluated between the 2 groups. Results: Laypeople are more prevailing in the COVID-19 vaccine--related discussion. Regarding differences in expression characteristics, the professionals posted longer answers and showed a conservative stance toward vaccine effectiveness than did laypeople. Laypeople mentioned countries more frequently, while professionals were inclined to raise medical jargon. STM discloses prominent topics under each question category. Statistical analysis revealed that laypeople preferred the ``safety of Chinese-made vaccine'' topic and other vaccine-related issues in other countries. However, the professionals paid more attention to medical principles and professional standards underlying the COVID-19 vaccine. With respect to topics associated with the social implications of vaccines, the 2 groups showed no significant difference. Conclusions: Our findings indicate that laypeople and professionals share some common grounds but also hold divergent focuses toward the COVID-19 vaccine issue. These incongruities can be summarized as ``qualitatively different'' in perspective rather than ``quantitatively different'' in scientific knowledge. Among those questions closely associated with medical expertise, the ``qualitatively different'' characteristic is quite conspicuous. This study boosts the current understanding of how the public perceives the COVID-19 vaccine, in a more nuanced way. Web-based question and answer forums are a bonanza for examining perception discrepancies among various identities. STM further exhibits unique strengths over the traditional topic modeling method in statistically testing the topic preference of diverse groups. Public health practitioners should be keenly aware of the cognitive differences between professionals and laypeople, and pay special attention to the topics with significant inconsistency across groups to build consensus and promote vaccination effectively. ", issn="1438-8871", doi="10.2196/30715", url="//www.mybigtv.com/2021/8/e30715", url="https://doi.org/10.2196/30715", url="http://www.ncbi.nlm.nih.gov/pubmed/34346885" }