对癌症幸存者的数字酒精节制干预的有效性、成本-效果和成本-效用:卡塔尔世界杯8强波胆分析一项实用主义随机对照试验的卫生经济评价和结果% a Mujcic,Ajla % a Blankers,Matthijs % a Boon,Brigitte % a Berman,Anne H % a Riper,Heleen % a van Laar,Margriet % a Engels,Rutger %+ Erasmus社会和行为科学学院，鹿特丹伊拉斯谟大学，Burgemeester Oudlaan 50，鹿特丹，3062 PA，荷兰，31 30 29 59 256，amujcic@trimbos.nl %K酒精%K简短干预%K癌症幸存者%K有效性%K成本效益%K电子健康%K移动电话%D 2022 %7 1.2.2022 %9原始论文%J J医学互联网Res %G英语%X背景:酒精调节(AM)干预可能有助于更好的治疗结果和癌症幸存者的总体福祉。目的:本研究评估了数字AM干预MyCourse的有效性、成本效益和成本效用，并与非交互式数字癌症幸存者信息手册进行了比较。方法:采用实用的两臂平行组随机对照试验进行健康经济评估，并在随机化后3、6和12个月进行随访。这项研究于2016年至2019年在荷兰的网上进行。参与者是成年10年癌症幸存者，饮酒超过荷兰推荐的饮酒指南(每周≤7标准单位[10克酒精])，并有意适度或戒酒。总体而言，103名参与者被随机化并进行分析:MyCourse组53人(51.5%)，对照组50人(48.5%)。在“我的课程”组中，参与者可以获得一种新开发的、数字的、最低限度引导的AM干预，“我的课程-适度饮酒”。主要结果是在6个月随访时，在过去7天内摄入标准饮料(10克乙醇)的自我报告数量。 The secondary outcome measures were alcohol-related problems as measured by the Alcohol Use Disorders Identification Test (AUDIT) and treatment satisfaction. For the health economic evaluation, health care costs, costs because of productivity losses, and intervention costs were assessed over a 12-month horizon. Results: Alcohol use at the 6-month follow-up decreased by 38% in the MyCourse group and by 33% in the control group. No difference in 7-day alcohol use was found between the groups (B=2.1, 95% CI −7.6 to 3.1; P=.22) at any of the follow-ups. AUDIT scores for alcohol-related problems decreased over time in both groups, showing no significant difference between the groups (Cohen d=0.3, 95% CI −0.1 to 0.6; P=.21). Intervention costs per participant were estimated at US $279 for the MyCourse group and US $74 for the control group. The mean societal costs were US $18,092 (SD 25,662) and US $23,496 (SD 34,327), respectively. The MyCourse group led to fewer gained quality-adjusted life years at lower societal costs in the cost-utility analysis. In the cost-effectiveness analysis, the MyCourse group led to a larger reduction in drinking units over time at lower societal costs (incremental cost-effectiveness ratio per reduced drink: US $ −1158, 95% CI −1609 to −781). Conclusions: At 6 months, alcohol use was reduced by approximately one-third in both groups, with no significant differences between the digital intervention MyCourse and a noninteractive web-based brochure. At 12 months, cost-effectiveness analyses showed that MyCourse led to a larger reduction in drinking units over time, at lower societal costs. The MyCourse group led to marginally fewer gained quality-adjusted life years, also at lower societal costs. Trial Registration: Netherlands Trial Register NTR6010; https://www.trialregister.nl/trial/5433 International Registered Report Identifier (IRRID): RR2-10.1186/s12885-018-4206-z %M 35103605 %R 10.2196/30095 %U //www.mybigtv.com/2022/2/e30095 %U https://doi.org/10.2196/30095 %U http://www.ncbi.nlm.nih.gov/pubmed/35103605